Article
Role of N-methyl-D-aspartate receptors in the neuroprotective activation of extracellular signal-regulated kinase 1/2 by cisplatin.
The Journal of biological chemistry - 31 Oct 2003
Gozdz Agata, Habas Agata, Jaworski Jacek, Zielinska Magdalena, Albrecht Jan, Chlystun Marcin, Jalili Ahmad, Hetman Michal
Abstract excerpt
Neurons are exposed to damaging stimuli that can trigger cell death and subsequently cause serious neurological disorders. Therefore, it is important to define defense mechanisms that can be activated in response to damage to reduce neuronal loss. Here we report that cisplatin (CPDD), a neurotoxi...
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