Article
Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9.
Cell cycle (Georgetown, Tex.) - 15 Jan 2013
Chee Jacqueline L Y, Saidin Suzan, Lane David P, Leong Sai Mun, Noll Jacqueline E, Neilsen Paul M, Phua Yi Ting, Gabra Hani, Lim Tit Meng
Abstract excerpt
The p53 gene has been implicated in many cancers due to its frequent mutations as well as mutations in other genes whose proteins directly affect p53's functions. In addition, high expression of p53 [wild-type (WT) or mutant] has been found in the cytoplasm of many tumor cells, and studies have associated these observations with more aggressive tumors and poor prognosis. Cytoplasmic mis-localization of p53...
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