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Article

Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways.

Cancer research - 1 Sept 2000

Zeng M, Narayanan L, Xu X S, Prolla T A, Liskay R M, Glazer P M

Abstract excerpt

The cytotoxicity of ionizing radiation (IR) has been associated with both the p53 pathway and with DNA mismatch repair (MMR). p53 mediates cell cycle arrest and apoptosis in response to X-ray damage, whereas the MMR complex is thought to recognize damaged bases and initiate a signal transduction pathway that can include phosphorylation of p53. To determine whether p53 and MMR mediate X-ray cytotoxicity via the...

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Source

Identifiers

PMID: 10987303

Genes

PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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