Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 regulates a non-apoptotic death induced by ROS.

Cell death and differentiation - 1 Nov 2013

Montero J, Dutta C, van Bodegom D, Weinstock D, Letai A

Abstract excerpt

DNA damage induced by reactive oxygen species and several chemotherapeutic agents promotes both p53 and poly (ADP-ribose) polymerase (PARP) activation. p53 activation is well known to regulate apoptotic cell death, whereas robust activation of PARP-1 has been shown to promote a necrotic cell death associated with energetic collapse. Here we identify a novel role for p53 in modulating PARP enzymatic activity to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to DNA Damage
Share to HCT116 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen Peroxide

Share to MCF-7 Cells

Share to Poly (ADP-Ribose) Polymerase-1

Share to Poly(ADP-ribose) Polymerases

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 23703322
DOI: 10.1038/cdd.2013.52
PMCID: PMC3792438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 regulates a non-apoptotic death induced by ROS.PMID 23703322Read ↗

p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseasesSemantic proximity Read ↗

p53: DNA damage, DNA repair, and apoptosis.Semantic proximity Read ↗

Mitochondrial death functions of p53Semantic proximity Read ↗

PARP-1: a critical regulator in radioprotection and radiotherapy-mechanisms, challenges, and therapeutic opportunitiesSemantic proximity Read ↗

Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?Semantic proximity Read ↗

The cell death machinery governed by the p53 tumor suppressor in response to DNA damageSemantic proximity Read ↗

The cell death machinery governed by the p53 tumor suppressor in response to DNA damageSemantic proximity Read ↗

Role of p53 mutations in the radiosensitivity status of tumor cells.Semantic proximity Read ↗

PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer CellsSemantic proximity Read ↗

DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.Semantic proximity Read ↗

[Antioncogene p53 and apoptosis response: new hypotheses on the molecular bases of tumor resistance to radiotherapy].Semantic proximity Read ↗

Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.