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Structural and Functional Dissection of the Heterocyclic Peptide Cytotoxin Streptolysin S

14 Mar 2009

Abstract excerpt

The human pathogen Streptococcus pyogenes secretes a highly cytolytic toxin known as streptolysin S (SLS). SLS is a key virulence determinant and responsible for the beta-hemolytic phenotype of these bacteria. Despite over a century of research, the chemical structure of SLS remains unknown. Recent experiments have revealed that SLS is generated from an inactive precursor peptide that undergoes extensive...

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PMID: 19286651
DOI: 10.1074/jbc.m900802200

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