Article
Host-Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity.
Toxins - 6 Feb 2020
Tromp Angelino T, Van Gent Michiel, Jansen Joris P, Scheepmaker Lisette M, Velthuizen Anneroos, De Haas Carla J C, Van Kessel Kok P M, Bardoel Bart W, Boettcher Michael, McManus Michael T, Van Strijp Jos A G, Lebbink Robert Jan, Haas Pieter-Jan A, Spaan András N
Abstract excerpt
Staphylococcal bi-component pore-forming toxins, also known as leukocidins, target and lyse human phagocytes in a receptor-dependent manner. S-components of the leukocidins Panton-Valentine leukocidin (PVL), γ-haemolysin AB (HlgAB) and CB (HlgCB), and leukocidin ED (LukED) specifically employ receptors that belong to the class of G-protein coupled receptors (GPCRs). Although these receptors share a common...
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