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Article

Targeted Amino Acid Substitutions Impair Streptolysin O Toxicity and Group A <i>Streptococcus</i> Virulence

9 Jan 2013

Abstract excerpt

UNLABELLED: Streptolysin O is a potent pore-forming toxin produced by group A Streptococcus. The aims of the present study were to dissect the relative contributions of different structural domains of the protein to hemolytic activity, to obtain a detoxified form of streptolysin O amenable to human vaccine formulation, and to investigate the role of streptolysin O-specific antibodies in protection against group A...

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Identifiers

PMID: 23300245
DOI: 10.1128/mbio.00387-12

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