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Multimodal Mass Spectrometry Identifies a Conserved Protective Epitope in S. pyogenes Streptolysin O

3 May 2024

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide An important element of antibody-guided vaccine design is the use of neutralizing or opsonic monoclonal antibodies to define protective epitopes in their native three-dimensional conformation. Here, we demonstrate a multimodal mass spectrometry-based strategy for in-depth characterization of antigen–antibody complexes to enable the identification of protective...

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Share to Bacterial Identification and Susceptibility Testing
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PMID: 38701337
DOI: 10.1021/acs.analchem.4c00596

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