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Clostridiolysin S, a Post-translationally Modified Biotoxin from Clostridium botulinum

26 Jun 2010

Abstract excerpt

Through elaboration of its botulinum toxins, Clostridium botulinum produces clinical syndromes of infant botulism, wound botulism, and other invasive infections. Using comparative genomic analysis, an orphan nine-gene cluster was identified in C. botulinum and the related foodborne pathogen Clostridium sporogenes that resembled the biosynthetic machinery for streptolysin S, a key virulence factor from group A...

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PMID: 20581111
DOI: 10.1074/jbc.m110.118554

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