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Article

Wild type beta-2 microglobulin and DE loop mutants display a common fibrillar architecture.

PloS one - 1 Jan 2015

Natalello Antonino, Relini Annalisa, Penco Amanda, Halabelian Levon, Bolognesi Martino, Doglia Silvia Maria, Ricagno Stefano

Abstract excerpt

Beta-2 microglobulin (β2m) is the protein responsible for a pathologic condition known as dialysis related amyloidosis. In recent years an important role has been assigned to the peptide loop linking strands D and E (DE loop) in determining β2m stability and amyloid propensity. Several mutants of the DE loop have been studied, showing a good correlation between DE loop geometrical strain, protein stability and...

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Share to Amyloid
Share to Amyloidosis
Share to beta 2-Microglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Atomic Force

Share to Protein Aggregation, Pathological

Share to Protein Stability

Share to Renal Dialysis

Share to Spectrophotometry, Infrared

Source

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Identifiers

PMID: 25803608
DOI: 10.1371/journal.pone.0122449
PMCID: PMC4372401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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