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Disease-relevant β2-microglobulin variants share a common amyloid fold

2 Mar 2023

Abstract excerpt

Abstract β2-microglobulin (β2m) and its truncated variant ΔΝ6 are co-deposited in amyloid fibrils in the joints, causing the disorder dialysis-related amyloidosis (DRA). Point mutations of β2m result in diseases with distinct pathologies. β2m-D76N causes a rare systemic amyloidosis with protein deposited in the viscera in the absence of renal failure, whilst β2m-V27M is associated with renal failure, with amyloid...

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PMID: 36864041
DOI: 10.1038/s41467-023-36791-8

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