Article
DE loop mutations affect beta2-microglobulin stability and amyloid aggregation.
Biochemical and biophysical research communications - 5 Dec 2008
Ricagno Stefano, Colombo Matteo, de Rosa Matteo, Sangiovanni Enrico, Giorgetti Sofia, Raimondi Sara, Bellotti Vittorio, Bolognesi Martino
Abstract excerpt
Beta2-microglobulin (beta2m) is the light chain component of class I major histocompatibility complex (MHC-I). beta2m is an intrinsically amyloidogenic protein that can assemble into amyloid fibrils in vitro and in vivo. Several recent reports suggested that the polypeptide loop comprised between beta-strands D and E of beta2m is important for protein stability and for the protein propensity to aggregate as...
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