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Article

Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis.

PloS one - 1 Jan 2015

de Rosa Matteo, Barbiroli Alberto, Giorgetti Sofia, Mangione Patrizia P, Bolognesi Martino, Ricagno Stefano

Abstract excerpt

D76N is the first natural variant of human β-2 microglobulin (β2m) so far identified. Contrary to the wt protein, this mutant readily forms amyloid fibres in physiological conditions, leading to a systemic and severe amyloidosis. Although the Asp76Asn mutant has been extensively characterized, the molecular bases of its instability and aggregation propensity remain elusive. In this work all Asp residues of human...

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Identifiers

PMID: 26625273
DOI: 10.1371/journal.pone.0144061
PMCID: PMC4666650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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