Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase

9 Mar 2010

Abstract excerpt

WRN protein loss causes Werner syndrome (WS), which is characterized by premature aging as well as genomic and telomeric instability. WRN prevents telomere loss, but the telomeric protein complex must regulate WRN activities to prevent aberrant telomere processing. Telomere-binding TRF2 protein inhibits telomere t-loop deletion by blocking Holliday junction (HJ) resolvase cleavage activity, but whether TRF2 also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal and Genetic Variations
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20215438
DOI: 10.1093/nar/gkq144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicasePMID 20215438Read ↗

WRN Controls Formation of Extrachromosomal Telomeric Circles and Is Required for TRF2<sup>ΔB</sup>-Mediated Telomere ShorteningSemantic proximity Read ↗

TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNASemantic proximity Read ↗

WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1Semantic proximity Read ↗

Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome HelicasesSemantic proximity Read ↗

The Werner Syndrome Helicase and Exonuclease Cooperate to Resolve Telomeric D Loops in a Manner Regulated by TRF1 and TRF2Semantic proximity Read ↗

Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletionsSemantic proximity Read ↗

ZNF524 directly interacts with telomeric DNA and supports telomere integritySemantic proximity Read ↗

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with TelomeresSemantic proximity Read ↗

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop UnwindingSemantic proximity Read ↗

Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the TelomereSemantic proximity Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome ProteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.