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Article

Cell culture-adaptive mutations in hepatitis C virus promote viral production by enhancing viral replication and release.

World journal of gastroenterology - 28 Mar 2018

Wang Qi, Li Yue, Liu Shun-Ai, Xie Wen, Cheng Jun

Abstract excerpt

AIM: To explore hepatitis C virus (HCV) adaptive mutations or combinations thereof responsible for enhanced viral production and investigate the underlying mechanisms. METHODS: A series of plasmids with adaptive mutations were constructed. After the plasmids were transfected into Huh7.5 cells, we determined the infectious HCV particle titers by NS5A immunofluorescence assays, and detected HCV RNA replication by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29599605
DOI: 10.3748/wjg.v24.i12.1299
PMCID: PMC5871825

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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