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Telomere Position Effect and Silencing of Transgenes near Telomeres in the Mouse

14 Feb 2006

Abstract excerpt

Reversible transcriptional silencing of genes located near telomeres, termed the telomere position effect (TPE), is well characterized in Saccharomyces cerevisiae. TPE has also been observed in human tumor cell lines, but its function remains unknown. To investigate TPE in normal mammalian cells, we developed clones of mouse embryonic stem (ES) cells that contain single-copy marker genes integrated adjacent to...

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PMID: 16479005
DOI: 10.1128/mcb.26.5.1865-1878.2006

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