Article
Evidence that silencing of the HPRT promoter by DNA methylation is mediated by critical CpG sites.
The Journal of biological chemistry - 5 Jan 2001
Chen C, Yang M C, Yang T P
Abstract excerpt
The strong correlation between promoter hypermethylation and gene silencing suggests that promoter methylation represses transcription. To identify methylation sites that may be critical for maintaining repression of the human HPRT gene, we treated human/hamster hybrid cells containing an inactive human X chromosome with the DNA demethylating agent 5-azadeoxycytidine (5aCdr), and we then examined the high...
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