Article

Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis

2022-04-22

Abstract excerpt

HOTAIR is a 2.2 kb long noncoding RNA (lncRNA) whose dysregulation has been linked to oncogenesis, defects in pattern formation during early development, and irregularities during the process of epithelial-to-mesenchymal transition (EMT). However, the oncogenic transformation determined by HOTAIR in vivo and its impact on chromatin dynamics are incompletely understood. Here we generate a transgenic mouse model wit...

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Literature Corpus work: f7fbbf09-dce9-51a7-ad24-960631a1ef17
DOI: 10.1101/2022.04.21.488980

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