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Article

Selection of a simian-human immunodeficiency virus strain resistant to a vaginal microbicide in macaques.

Journal of virology - 1 May 2009

Dudley Dawn M, Wentzel Jennifer L, Lalonde Matthew S, Veazey Ronald S, Arts Eric J

Abstract excerpt

PSC-RANTES binds to CCR5, inhibits human immunodeficiency virus type 1 (HIV-1) entry, and has been shown as a vaginal microbicide to protect rhesus macaques from a simian-human immunodeficiency virus chimera (SHIV(SF162-p3)) infection in a dose-dependent manner. In this study, env gene sequences from SHIV(SF162-p3)-infected rhesus macaques treated with PSC-RANTES were analyzed for possible drug escape variants....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 19279098
DOI: 10.1128/JVI.00055-09
PMCID: PMC2682063

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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