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Article

Generation and mucosal transmissibility of emtricitabine- and tenofovir-resistant SHIV162P3 mutants in macaques.

Virology - 10 Apr 2011

Cong Mian-er, Youngpairoj Ae S, Aung Wutyi, Sharma Sunita, Mitchell James, Dobard Charles, Heneine Walid, Garcia-Lerma J Gerardo

Abstract excerpt

Transmission of drug-resistant HIV has been widely documented. We generated tenofovir (TFV)- and emtricitabine (FTC)-resistant SHIV162P3 mutants that can be used to investigate the transmission efficiency of drug-resistant viruses and their impact on the efficacy of pre-exposure prophylaxis. Both SHIV162p3(M184V) and SHIV162p3(K65R) replicated in vitro at high titers. Drug resistance profiles were similar to...

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Identifiers

PMID: 21334708
DOI: 10.1016/j.virol.2011.01.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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