Article
In vivo evolution of env in SHIV-AD8EO-infected rhesus macaques after AAV-vectored delivery of eCD4-Ig.
Molecular therapy : the journal of the American Society of Gene Therapy - 5 Feb 2025
O'Hagan Daniel, Shandilya Siddhartha, Hopkins Lincoln J, Hahn Patricia A, Fuchs Sebastian P, Martinez-Navio José M, Alpert Michael D, Gardner Mathew R, Desrosiers Ronald C, Gao Guangping, Lifson Jeffrey D, Farzan Michael, Ardeshir Amir, Martins Mauricio A
Abstract excerpt
eCD4-immunoglobulin (Ig) is an HIV entry inhibitor that mimics the engagement of both CD4 and CCR5 with the HIV envelope (Env) protein, a property that imbues it with remarkable potency and breadth. However, env is exceptionally genetically malleable and can evolve to escape a wide variety of entry inhibitors. Here we document the evolution of partial eCD4-Ig resistance in SHIV-AD8EO-infected rhesus macaques...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.