Article
Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy.
Journal of virology - 1 Nov 2007
Ambrose Zandrea, Palmer Sarah, Boltz Valerie F, Kearney Mary, Larsen Kay, Polacino Patricia, Flanary Leon, Oswald Kelli, Piatak Michael, Smedley Jeremy, Shao Wei, Bischofberger Norbert, Maldarelli Frank, Kimata Jason T, Mellors John W, Hu Shiu-Lok, Coffin John M, Lifson Jeffrey D, KewalRamani Vineet N
Abstract excerpt
Antiretroviral therapy (ART) in human immunodeficiency virus type 1 (HIV-1)-infected patients does not clear the infection and can select for drug resistance over time. Not only is drug-resistant HIV-1 a concern for infected individuals on continual therapy, but it is an emerging problem in resource-limited settings where, in efforts to stem mother-to-child-transmission of HIV-1, transient nonnucleoside reverse...
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