Article
Rapamycin alleviates toxicity of different aggregate-prone proteins.
Human molecular genetics - 1 Feb 2006
Berger Zdenek, Ravikumar Brinda, Menzies Fiona M, Oroz Lourdes Garcia, Underwood Benjamin R, Pangalos Menelas N, Schmitt Ina, Wullner Ullrich, Evert Bernd O, O'Kane Cahir J, Rubinsztein David C
Abstract excerpt
Many neurodegenerative diseases are caused by intracellular, aggregate-prone proteins, including polyglutamine-expanded huntingtin in Huntington's disease (HD) and mutant tau in fronto-temporal dementia/tauopathy. Previously, we showed that rapamycin, an autophagy inducer, enhances mutant huntingtin fragment clearance and attenuated toxicity. Here we show much wider applications for this approach. Rapamycin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.