Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Jan 2016

Gentry Erik G, Henderson Benjamin W, Arrant Andrew E, Gearing Marla, Feng Yangbo, Riddle Nicole C, Herskowitz Jeremy H

Abstract excerpt

Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neurodegenerative four-repeat tauopathies with no cure. Mitigating pathogenic tau levels is a rational strategy for tauopathy treatment, but therapeutic targets with clinically available drugs are lacking. Here, we report that protein levels of the Rho-associated protein kinases (ROCK1 and ROCK2), p70 S6 kinase (S6K), and mammalian...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basal Ganglia Diseases
Share to Nerve Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuroblastoma

Share to rho-Associated Kinases

Share to Ribosomal Protein S6 Kinases, 70-kDa

Share to Supranuclear Palsy, Progressive

Share to tau Proteins

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 26818518
DOI: 10.1523/JNEUROSCI.2336-15.2016
PMCID: PMC4728727

Genes

ROCK2
ROCK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration.PMID 26818518Read ↗

ROCK inhibition in models of neurodegeneration and its potential for clinical translationSemantic proximity Read ↗

What Is the Role of the Rho-ROCK Pathway in Neurologic Disorders?Semantic proximity Read ↗

A screen for regulators of survival of motor neuron protein levels.Semantic proximity Read ↗

Chronic Rapamycin administration via drinking water mitigates the pathological phenotype in a Krabbe disease mouse model through autophagy activation.Semantic proximity Read ↗

<scp>mTOR</scp> regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathiesSemantic proximity Read ↗

Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice.Semantic proximity Read ↗

A Critical Kinase Cascade In Neurological Disorders: Pi3K, Akt and MtorSemantic proximity Read ↗

Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulationSemantic proximity Read ↗

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.Semantic proximity Read ↗

Non-neuronal, TGF-β–driven extracellular matrix restructuring promotes neurodegeneration in a PSP-Richardson syndrome modelSemantic proximity Read ↗

Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinsons linked-LRRK2 mutant miceSemantic proximity Read ↗

n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.