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Article

ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT

28 Aug 2012

Abstract excerpt

BACKGROUND: Huntington's Disease (HD) is a fatal hereditary neurodegenerative disease caused by the accumulation of mutant huntingtin protein (Htt) containing an expanded polyglutamine (polyQ) tract. Activation of the channel responsible for the inositol-induced Ca²⁺ release from ensoplasmic reticulum (ER), was found to contribute substantially to neurodegeneration in HD. Importantly, chemical and genetic...

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PMID: 22929228
DOI: 10.1186/1750-1326-7-43

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