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Article

Huntington's disease: degradation of mutant huntingtin by autophagy.

The FEBS journal - 1 Sept 2008

Sarkar Sovan, Rubinsztein David C

Abstract excerpt

Autophagy is a nonspecific bulk degradation pathway for long-lived cytoplasmic proteins, protein complexes, or damaged organelles. This process is also a major degradation pathway for many aggregate-prone, disease-causing proteins associated with neurodegenerative disorders, such as mutant huntingtin in Huntington's disease. In this review, we discuss factors regulating the degradation of mutant huntingtin by...

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Identifiers

PMID: 18637946
DOI: 10.1111/j.1742-4658.2008.06562.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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