Article
Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy.
Haematologica - 1 Apr 2009
Nowak Daniel, Le Toriellec Emilie, Stern Marc-Henri, Kawamata Norihiko, Akagi Tadayuki, Dyer Martin J, Hofmann Wolf-Karsten, Ogawa Seishi, Koeffler H Phillip
Abstract excerpt
BACKGROUND: T-cell prolymphocytic leukemia is a rare aggressive lymphoproliferative disease with a mature T-cell phenotype and characteristic genomic lesions such as inv(14)(q11q34), t(14;14)(q11;q32) or t(X;14)(q28;q11), mutation of the ATM gene on chromosome 11 and secondary alterations such as deletions of chromosome 8p and duplications of 8q. DESIGN AND METHODS: We analyzed malignant cells from 18 patients...
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