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Article

Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression.

Blood - 7 Jul 2011

Klampfl Thorsten, Harutyunyan Ashot, Berg Tiina, Gisslinger Bettina, Schalling Martin, Bagienski Klaudia, Olcaydu Damla, Passamonti Francesco, Rumi Elisa, Pietra Daniela, Jäger Roland, Pieri Lisa, Guglielmelli Paola, Iacobucci Ilaria, Martinelli Giovanni, Cazzola Mario, Vannucchi Alessandro M, Gisslinger Heinz, Kralovics Robert

Abstract excerpt

Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are clonal myeloid disorders with increased production of terminally differentiated cells. The disease course is generally chronic, but some patients show disease progression (secondary myelofibrosis or accelerated phase) and/or leukemic transformation. We investigated chromosomal aberrations in 408 MPN samples using high-resolution...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21531982
DOI: 10.1182/blood-2011-01-331678

Genes

CUX1
ETV6
FOXP1
IKZF1
JAK2
RUNX1
TET2

Provenance

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