Article
Linking genomic lesions with minimal residual disease improves prognostic stratification in children with T-cell acute lymphoblastic leukaemia.
Leukemia research - 1 Aug 2013
La Starza Roberta, Lettieri Antonella, Pierini Valentina, Nofrini Valeria, Gorello Paolo, Songia Simona, Crescenzi Barbara, Te Kronnie Geertruy, Giordan Marco, Leszl Anna, Valsecchi Maria Grazia, Aversa Franco, Basso Giuseppe, Biondi Andrea, Conter Valentino, Cazzaniga Giovanni, Mecucci Cristina
Abstract excerpt
Multiple lesions in genes that are involved in cell cycle control, proliferation, survival and differentiation underlie T-cell acute lymphoblastic leukaemia (T-ALL). We translated these biological insights into clinical practice to improve diagnostic work-ups and patient management. Combined interphase fluorescence in situ hybridization (CI-FISH), single nucleotide polymorphism (SNP), and gene expression profiles...
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