Article
Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32).
Leukemia - 1 Oct 2007
Dürig J, Bug S, Klein-Hitpass L, Boes T, Jöns T, Martin-Subero J I, Harder L, Baudis M, Dührsen U, Siebert R
Abstract excerpt
T-cell prolymphocytic leukemia (T-PLL) is a rare aggressive lymphoma derived from mature T cells, which is, in most cases, characterized by the presence of an inv(14)(q11q32)/t(14;14)(q11;q32) and a characteristic pattern of secondary chromosomal aberrations. DNA microarray technology was employe...
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