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Article

Potential role of cytochrome P450-1B1 in the metabolic activation of 4-aminobiphenyl in humans.

Molecular carcinogenesis - 1 Aug 2009

Ketelslegers Hans B, Godschalk Roger W L, Eskens Bart J M, Dallinga Jan W, Gottschalk Ralph W H, van Schooten Frederik J, van Delft Joost H M, Kleinjans Jos C S

Abstract excerpt

Metabolites of the human carcinogen 4-aminobiphenyl (4-ABP) form hemoglobin (Hb) adducts, which represent a useful biomarker for exposure. However, not every individual responds to a similar degree to 4-ABP exposure, and variations in 4-ABP-Hb adduct formation might be explained by genetic polymorphisms in genes coding for enzymes involved in 4-ABP metabolism. 4-ABP-Hb adducts were measured in blood samples from...

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Identifiers

PMID: 19274671
DOI: 10.1002/mc.20530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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