Article
Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant.
Pharmacogenetics - 1 Jul 2002
Lo-Guidice Jean-Marc, Allorge Delphine, Cauffiez Christelle, Chevalier Dany, Lafitte Jean-Jacques, Lhermitte Michel, Broly Franck
Abstract excerpt
In the present study, we report the first systematic investigation of polymorphism in the human CYP4B1 gene. Using a strategy based on single-strand conformation polymorphism analysis of PCR products (PCR-SSCP), we analyzed the twelve exons of the gene, as well as their 5'- and 3'- proximal flanking sequences, in DNA samples from 190 French Caucasians. In addition to the wild-type CYP4B1* allele (CYP4B1*1), four...
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