Article
CYP1A2 and NAT2 phenotyping and 3-aminobiphenyl and 4-aminobiphenyl hemoglobin adduct levels in smokers and non-smokers.
Toxicology and applied pharmacology - 15 Jun 2006
Sarkar Mohamadi, Stabbert Regina, Kinser Robin D, Oey Jan, Rustemeier Klaus, von Holt Klaus, Schepers Georg, Walk Roger A, Roethig Hans J
Abstract excerpt
Some aromatic amines are considered to be putative bladder carcinogens. Hemoglobin (Hb) adducts of 3-aminobiphenyl (3-ABP) and 4-aminobiphenyl (4-ABP) have been used as biomarkers of exposure to aromatic amines from cigarette smoke. One of the goals of this study was to determine intra- and inter-individual variability in 3-ABP and 4-ABP Hb adducts and to explore the predictability of ABP Hb adduct levels based...
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