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Article

Influence of metabolic genotypes on biomarkers of exposure to 1,3-butadiene in humans.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2002

Fustinoni Silvia, Soleo Leonardo, Warholm Margareta, Begemann Petra, Rannug Agneta, Neumann Hans-G, Swenberg James A, Vimercati Luigi, Colombi Antonio

Abstract excerpt

Carcinogenicity of 1,3-butadiene (BD) has been linked to its metabolic activation of genotoxic epoxides. The inherited variations in the activity of BD-metabolizing enzymes may be responsible for individual differences that modulate the effects of BD exposure. In this study, 40 Italian subjects (30 BD-exposed workers and 10 clerks) were investigated to evaluate the role of genetic polymorphism of cytochromes P450...

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Identifiers

PMID: 12376511

Genes

GSTM1
GSTT1
GSTP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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