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Characterization of common CYP1B1 variants with different capacity for benzo[a]pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene.

Cancer research - 15 Jun 2005

Aklillu Eleni, Øvrebø Steinar, Botnen Ingrid V, Otter Charlotta, Ingelman-Sundberg Magnus

Abstract excerpt

Cytochrome P450 1B1 (CYP1B1), an extrahepatic enzyme inducible by smoking, is overexpressed in many tumors and catalyzes the metabolic activation of procarcinogens such as polycyclic aromatic hydrocarbons. In human, CYP1B1 is genetically polymorphic and five common missense mutations causing amino acid substitution have been identified. In this study, we have investigated CYP1B1 haplotypes present in a Spanish...

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PMID: 15958554
DOI: 10.1158/0008-5472.CAN-05-0113

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