Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.

doi:10.1038/ng.336

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Article

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.

Nature genetics - 1 Apr 2009

Northcott Paul A, Nakahara Yukiko, Wu Xiaochong, Feuk Lars, Ellison David W, Croul Sid, Mack Stephen, Kongkham Paul N, Peacock John, Dubuc Adrian, Ra Young-Shin, Zilberberg Karen, McLeod Jessica, Scherer Stephen W, Sunil Rao J, Eberhart Charles G, Grajkowska Wiesia, Gillespie Yancey, Lach Boleslaw, Grundy Richard, Pollack Ian F, Hamilton Ronald L, Van Meter Timothy, Carlotti Carlos G, Boop Frederick, Bigner Darrell, Gilbertson Richard J, Rutka James T, Taylor Michael D

Abstract excerpt

We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the genomes of 212 medulloblastomas, malignant pediatric brain tumors. We found focal amplifications of 15 known oncogenes and focal deletions of 20 known tumor suppressor genes (TSG), most not previously implicated in medulloblastoma. Notably, we identified previously unknown amplifications and homozygous deletions, including...

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Identifiers

PMID: 19270706
DOI: 10.1038/ng.336
PMCID: PMC4454371

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