Article
The whole-genome landscape of medulloblastoma subtypes.
Nature - 19 Jul 2017
Northcott Paul A, Buchhalter Ivo, Morrissy A Sorana, Hovestadt Volker, Weischenfeldt Joachim, Ehrenberger Tobias, Gröbner Susanne, Segura-Wang Maia, Zichner Thomas, Rudneva Vasilisa A, Warnatz Hans-Jörg, Sidiropoulos Nikos, Phillips Aaron H, Schumacher Steven, Kleinheinz Kortine, Waszak Sebastian M, Erkek Serap, Jones David T W, Worst Barbara C, Kool Marcel, Zapatka Marc, Jäger Natalie, Chavez Lukas, Hutter Barbara, Bieg Matthias, Paramasivam Nagarajan, Heinold Michael, Gu Zuguang, Ishaque Naveed, Jäger-Schmidt Christina, Imbusch Charles D, Jugold Alke, Hübschmann Daniel, Risch Thomas, Amstislavskiy Vyacheslav, Gonzalez Francisco German Rodriguez, Weber Ursula D, Wolf Stephan, Robinson Giles W, Zhou Xin, Wu Gang, Finkelstein David, Liu Yanling, Cavalli Florence M G, Luu Betty, Ramaswamy Vijay, Wu Xiaochong, Koster Jan, Ryzhova Marina, Cho Yoon-Jae, Pomeroy Scott L, Herold-Mende Christel, Schuhmann Martin, Ebinger Martin, Liau Linda M, Mora Jaume, McLendon Roger E, Jabado Nada, Kumabe Toshihiro, Chuah Eric, Ma Yussanne, Moore Richard A, Mungall Andrew J, Mungall Karen L, Thiessen Nina, Tse Kane, Wong Tina, Jones Steven J M, Witt Olaf, Milde Till, Von Deimling Andreas, Capper David, Korshunov Andrey, Yaspo Marie-Laure, Kriwacki Richard, Gajjar Amar, Zhang Jinghui, Beroukhim Rameen, Fraenkel Ernest, Korbel Jan O, Brors Benedikt, Schlesner Matthias, Eils Roland, Marra Marco A, Pfister Stefan M, Taylor Michael D, Lichter Peter
Abstract excerpt
Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose debilitating effects on the developing child, and highlight the need for molecularly targeted treatments with reduced toxicity. Previous studies have been unable to identify the full spectrum of driver genes and molecular processes that operate in medulloblastoma subgroups. Here we analyse the somatic landscape across 491...
Read the complete abstract on PubMed