Article
Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.
Acta neuropathologica - 1 Mar 2013
Dubuc Adrian M, Remke Marc, Korshunov Andrey, Northcott Paul A, Zhan Shing H, Mendez-Lago Maria, Kool Marcel, Jones David T W, Unterberger Alexander, Morrissy A Sorana, Shih David, Peacock John, Ramaswamy Vijay, Rolider Adi, Wang Xin, Witt Hendrik, Hielscher Thomas, Hawkins Cynthia, Vibhakar Rajeev, Croul Sidney, Rutka James T, Weiss William A, Jones Steven J M, Eberhart Charles G, Marra Marco A, Pfister Stefan M, Taylor Michael D
Abstract excerpt
Recent sequencing efforts have described the mutational landscape of the pediatric brain tumor medulloblastoma. Although MLL2 is among the most frequent somatic single nucleotide variants (SNV), the clinical and biological significance of these mutations remains uncharacterized. Through targeted re-sequencing, we identified mutations of MLL2 in 8 % (14/175) of MBs, the majority of which were loss of function....
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