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Article

Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2

29 Jul 2008

Abstract excerpt

Candidate gene investigations have indicated a significant role for epigenetic events in the pathogenesis of medulloblastoma, the most common malignant brain tumor of childhood. To assess the medulloblastoma epigenome more comprehensively, we undertook a genomewide investigation to identify genes that display evidence of methylation-dependent regulation. Expression microarray analysis of medulloblastoma cell...

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PMID: 18664619
DOI: 10.1215/15228517-2008-048

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