Article
Medulloblastoma biology in the post-genomic era.
Future oncology (London, England) - 1 Dec 2012
Archer Tenley C, Pomeroy Scott L
Abstract excerpt
Medulloblastomas, the most common malignant pediatric brain tumors, are comprised of four molecularly distinct subtypes. However, treatment has yet to exploit these molecular vulnerabilities. Three recent studies sequenced a total of 310 primary tumors and identified that two of the four medulloblastoma subtypes are concomitantly associated with subtype-specific mutations as previously characterized. In contrast,...
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