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Article

Ferritin contains less iron (59Fe) in cells when the protein pores are unfolded by mutation.

The Journal of biological chemistry - 14 Nov 2008

Hasan Mohammad R, Tosha Takehiko, Theil Elizabeth C

Abstract excerpt

Ferric minerals in ferritins are protected from cytoplasmic reductants and Fe2+ release by the protein nanocage until iron need is signaled. Deletion of ferritin genes is lethal; two critical ferritin functions are concentrating iron and oxidant protection (consuming cytoplasmic iron and oxygen in the mineral). In solution, opening/closing (gating) of eight ferritin protein pores controls reactions between...

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Identifiers

PMID: 18805796
DOI: 10.1074/jbc.M806025200
PMCID: PMC2581568

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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