Article
Investigating the role of the human CIA2A-CIAO1 complex in the maturation of aconitase.
Biochimica et biophysica acta. General subjects - 1 Sept 2018
Maione Vincenzo, Cantini Francesca, Severi Mirko, Banci Lucia
Abstract excerpt
BACKGROUND: The CIA2A protein, in complex with CIAO1, has been proposed to be exclusively implicated in the maturation of cytosolic aconitase. However, how the CIA2A-CIAO1 complex generates active aconitase is still unknown and the available structural information has not provided any crucial insights into the molecular function of CIA2A. METHODS: In this work we have characterized the Fe/S cluster binding...
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