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Article

Influenza virus ts61S hemagglutinin is significantly defective in polypeptide folding and intracellular transport at the permissive temperature.

Virology - 1 Nov 1991

Simpson D A, Lamb R A

Abstract excerpt

The influenza virus hemagglutinin (HA) temperature-sensitive (ts) mutant, ts61S, contains a nucleotide change in RNA segment 4 which leads to an amino acid change at HA1 residue 110 of serine to proline. When ts61S HA is synthesized and maintained at the nonpermissive temperature (39.5 degrees), the HA is defective in transport in the exocytic pathway and is retained in the endoplasmic reticulum (S. Nakajima, D....

Topics

Animals
Antibody Specificity
Cell Line
Exocytosis
Fluorescent Antibody Technique
Hemagglutinin Glycoproteins, Influenza Virus
Hemagglutinins, Viral
Influenza A virus
Kinetics
Mutation
Proline

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Protein Processing, Post-Translational

Serine

Temperature

Viral Envelope Proteins

Source

Identifiers

PMID: 1926789
DOI: 10.1016/0042-6822(91)90803-j

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1926789-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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