A conditional-lethal murine coronavirus mutant that fails to incorporate the spike glycoprotein into assembled virions.

doi:10.1016/0168-1702(95)00100-x

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Article

A conditional-lethal murine coronavirus mutant that fails to incorporate the spike glycoprotein into assembled virions.

Virus research - 1 Dec 1995

Ricard C S, Koetzner C A, Sturman L S, Masters P S

Abstract excerpt

The coronavirus spike glycoprotein (S) mediates both the attachment of virus to the host cell receptor and membrane fusion. We describe here the characterization of a temperature-sensitive mutant of the coronavirus mouse hepatitis virus A59 (MHV-A59) having multiple S protein-related defects. The...

Topics

Amino Acid Sequence
Animals
Cell Line
Genes, Viral
Membrane Glycoproteins
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Murine hepatitis virus
Mutation
Phenotype
Receptors, Virus
Sequence Analysis
Spike Glycoprotein, Coronavirus
Temperature
Viral Envelope Proteins
Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 8837889
DOI: 10.1016/0168-1702(95)00100-x
PMCID: PMC7134215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8837889-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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