Altered proteolytic processing of the polymerase polyprotein in RNA(-) temperature sensitive mutants of murine coronavirus.

doi:10.1007/978-1-4615-2996-5_34

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Article

Altered proteolytic processing of the polymerase polyprotein in RNA(-) temperature sensitive mutants of murine coronavirus.

Advances in experimental medicine and biology - 1 Jan 1993

Baker S C, Gao H, Baric R S

Abstract excerpt

We examined the synthesis and processing of the polymerase polyprotein in RNA(-) temperature sensitive mutant of murine coronavirus strain A59. These temperature sensitive mutants of MHV-A59 synthesize viral RNA at the permissive temperature (33.0 degrees C), but are unable to synthesize viral RN...

Topics

Genetic Complementation Test
Murine hepatitis virus
Mutation
Protein Precursors
Protein Processing, Post-Translational
RNA, Viral
Temperature
Transfection
Viral Proteins
Virus Replication

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