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Article

Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1.

Journal of virology - 1 Sept 2008

Lulla Valeria, Sawicki Dorothea L, Sawicki Stanley G, Lulla Aleksei, Merits Andres, Ahola Tero

Abstract excerpt

Alphavirus replicase protein nsP1 has multiple functions during viral RNA synthesis. It catalyzes methyltransferase and guanylyltransferase activities needed in viral mRNA capping, attaches the viral replication complex to cytoplasmic membranes, and is required for minus-strand RNA synthesis. Two temperature-sensitive (ts) mutations in Semliki Forest virus (SFV) were previously identified within nsP1: ts10...

Topics

Animals
Cell Line
Cricetinae
Cysteine Endopeptidases
Gene Expression Regulation, Viral
Membrane Fusion
Methyltransferases
Mutation
Nucleotidyltransferases
RNA Caps
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Viral

Recombination, Genetic

Semliki forest virus

Temperature

Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18596091
DOI: 10.1128/JVI.00711-08
PMCID: PMC2546902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18596091-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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