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Article

A serine-to-asparagine mutation at position 314 of H5N1 avian influenza virus NP is a temperature-sensitive mutation that interferes with nuclear localization of NP.

Archives of virology - 1 Jun 2013

Siboonnan Nattamon, Wiriyarat Wittawat, Boonarkart Chompunuch, Chakritbudsabong Warunya, Jongkaewwattana Anan, Puthavathana Pilaipan, Auewarakul Prasert, Suptawiwat Ornpreya

Abstract excerpt

We have generated a temperature-sensitive (ts) mutant from a human isolate of the H5N1 avian influenza virus by classical adaptation in cell culture. After 20 passages at low temperature, the virus showed a ts phenotype. The ts mutant also showed an attenuated phenotype after nasal inoculation in mice. Using reverse genetics, we generated reassortants carrying individual genomic segments of the wild-type and...

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PMID: 23307364
DOI: 10.1007/s00705-012-1595-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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