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Article

MDR1 haplotypes conferring an increased expression of intestinal CYP3A4 rather than MDR1 in female living-donor liver transplant patients.

Pharmaceutical research - 1 Jul 2009

Hosohata Keiko, Masuda Satohiro, Yonezawa Atsushi, Katsura Toshiya, Oike Fumitaka, Ogura Yasuhiro, Takada Yasutsugu, Egawa Hiroto, Uemoto Shinji, Inui Ken-Ichi

Abstract excerpt

PURPOSE: This study investigated whether haplotypes in the multidrug resistance 1 (MDR1) gene had effects on mRNA expression levels of MDR1 and cytochrome P450 (CYP) 3A4, and on the pharmacokinetics of tacrolimus in living-donor liver transplant (LDLT) patients, considering the gender difference. METHODS: Haplotype analysis of MDR1 with G2677T/A and C3435T was performed in 63 de novo Japanese LDLT patients (17 to...

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PMID: 19267185
DOI: 10.1007/s11095-009-9867-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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