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Article

Genetic polymorphism at the 5' regulatory region of multidrug resistance 1 (MDR1) and its association with interindividual variation of expression level in the colon.

Molecular cancer therapeutics - 1 Dec 2003

Taniguchi Shuichi, Mochida Yasushi, Uchiumi Takeshi, Tahira Tomoko, Hayashi Kenshi, Takagi Koichi, Shimada Mitsuo, Maehara Yoshihiko, Kuwano Hiroyuki, Kono Suminori, Nakano Hitoo, Kuwano Michihiko, Wada Morimasa

Abstract excerpt

The multidrug resistance 1 (MDR1) is a key molecule in determining not only the resistance of cancer cells to anticancer agents but also the disposition of a variety of drugs in intestinal and other tissues. However, the mechanism underlying interindividual variations in levels of MDR1 activity and expression in various tissues remains unclear. We analyzed the nucleotide sequence polymorphisms in the 5' upstream...

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PMID: 14707276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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