Article
Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients.
Journal of human genetics - 1 Jan 2004
Uwai Yuichi, Masuda Satohiro, Goto Maki, Motohashi Hideyuki, Saito Hideyuki, Okuda Masahiro, Nakamura Eijirou, Ito Noriyuki, Ogawa Osamu, Inui Ken-Ichi
Abstract excerpt
In this study, we have quantified the mRNA expression levels of multidrug resistance gene 1 (MDR1) in the normal kidney cortex and renal cell carcinoma (RCC) segments from 24 Japanese nephrectomized patients by real-time polymerase chain reaction (PCR). The mRNA expression level of MDR1 in RCC segments was significantly decreased in comparison with each normal segment (P=0.0042, by Student's paired t-test). In...
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